Varietal Differences in Kidney Beans Modulate Gut Microbiota and Inflammation During High-Fat Diet-Induced Obesity in Male Mice.

For epithelial barrier function, occludin showed a trend toward statistical significance ( p = 0.07), with highest expression in the BD group; it appeared lower in the HF group (trend p = 0.09), showing a possible disruption of barrier integrity in HF-fed mice.

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Occludin expression showed an overall trend ( p = 0.07), with a non-significant increase in both HF + WK and HF + DK groups compared to BD ( p = 0.1 for both bean groups), suggesting potential enhancement of barrier integrity with bean supplementation.

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Bean-fed mice exhibited modestly higher lean mass (~1 g) compared with HF at both timepoints, although these differences did not reach statistical significance ( Figure S1E ).

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