Mendelian randomization study of GLP-1R effects on ovarian cancer subtypes mediated by metabolic factors.

Commun Med (Lond) · 2026 · PMC12901151 · PMID 41526703

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closest p · 0.0× alpha

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highly significantP-value = 9.41 × 10−99actually significant

The SNP-based heritability estimated on the observed scale was 0.78% (SE = 0.04%), which was highly significant (Z = 21.09, P-value = 9.41 × 10−99), further supporting a polygenic basis for ovarian cancer.

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a clear trendno p-value reported

In addition, a clear trend was observed where QTLs from the deCODE, GoDMC, and eQTLGen consortia demonstrated higher F-statistics (sample sizes: 23,482–35,431; F-statistics: 54–162) compared to QTLs from GTEx v8 (sample sizes: 237–574; F-statistics: 14–28).

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nominally significantno p-value reported

Tissue-specific expression analysis revealed significant enrichment of associated genes in metabolically active tissues, most prominently in the kidney cortex (P adj -value = 6.30×10−5), with nominally significant enrichment in the gastrointestinal tract (transverse colon, P adj -value = 0.03).

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