Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive-Like Behaviors.

[ 21 , 50 ] Among astrocyte‐enriched synaptogenic factors, Thbs1 (encoding TSP1, an established astrocyte‐secreted protein that promotes excitatory synaptogenesis [ 32 ] ) showed a strong trend toward lower expression in PERK cKO mPFC tissue ( P = 0.0715; Figure 6E ), although this did not reach statistical significance.

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Spine head size remained stable over a 60‐min imaging session, although thin spines (head diameter < 1 μm) in PERK cKO mice showed a nonsignificant trend toward smaller head size (Figure 4D,E ).

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