Efficacy of Microneedle Fractional Radiofrequency Combined With Platelet-Rich Plasma for the Treatment of Melasma: A Split-Face, Randomized Trial.

J Cosmet Dermatol · 2026 · PMC12905025 · PMID 41689174

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showed a trendno p-value reported

After treatment, scores for wrinkles and UV spots showed a trend toward improvement on both sides, but these changes did not reach statistical significance ( p > 0.05).

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did not reach statistical significanceno p-value reported

VISIA analysis showed significant reductions in red area and brown spot scores on the combination side, whereas changes on the MFR‐alone side did not reach statistical significance.

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