Differential Left and Right Carotid Artery Blood Flow and Altered Hippocampal Mitochondrial Function After Transverse Aortic Constriction in Aging Rats.

J Am Heart Assoc · 2026 · PMC12909008 · PMID 41404745

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hedged sentences

0.0570

closest p · 1.1× alpha

0.0580

boldest claim

The sentences

did not reach statistical significanceP =0.057so close (0.05 < p ≤ 0.1)

Hippocampal Mitochondrial Respiration Is Impaired in the Right, But Not the Left, Hemisphere of TAC Animals At 40 weeks post‐TAC, a significant main effect of hemisphere ( F (1, 56)=5.08, P <0.05, ηp 2 =0.08) in CI‐linked coupled respiration was observed, and follow‐up contrast revealed that within condition hemispheric differences were greatest in TAC ( t (56)=1.94, P =0.057) than SHAM ( t (56)=1.18, P =0.24) animals, but these hemispheric differences within TAC animals did not reach statistical significance ( P =0.057) (Figure 2A ).

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approached significanceP =0.058so close (0.05 < p ≤ 0.1)

Last, because there was a main effect of hemisphere that approached significance ( F (1, 56)=3.75, P =0.058, ηp 2 =0.063) for CI&II‐linked coupled respiration, this was followed up with a contrast analysis, and the right hippocampus of TAC animals had significantly lower respiration rates than the left ( t (56)=−2.29, P =0.025) (Figure 2A ).

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