Intermittent ketogenic fasting with medium-chain triglycerides improves ataxia in COQ8A-related coenzyme Q10 deficiency: A case report.

Mol Genet Metab Rep · 2026 · PMC12914829 · PMID 41716779

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did not reach statistical significanceno p-value reported

investigated pediatric patients with mitochondrial disease including one patient with COQ8A-mutation on ketogenic regimens and reported significant seizure reductions, with some patients also showing improvement in motor symptoms such as ataxia, tremor, and dystonia, though these changes did not reach statistical significance [ 21 ].

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showed a trendno p-value reported

MRI showed a trend suggesting improved cerebellar microstructural integrity.

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