Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage.

Mol Psychiatry · 2026 · PMC12916286 · PMID 41006764

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did not reach statistical significanceno p-value reported

Also, the FTD neurons showed a weaker response to glutamate and reacted less strongly to depolarizing KCl as compared to control neurons, but these changes did not reach statistical significance.

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showed a trendno p-value reported

The fact that the number of p62/SQSTM1-positive vesicles was not concomitantly increased in the FTD neurons, but rather showed a trend towards a decrease could suggest defective clearance and enhanced fusion of the p62/SQSTM1-containing vesicles.

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