Microglial phagocytosis of bipolar cells triggers inner retinal degeneration in Rs1-KO mice.

Detailed quantification of ONL thickness revealed that while Rs1 −/y retinas showed a trend toward thinning at 8 weeks, the difference was not statistically significant (Supplementary Figure S2A).

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While microglia represented a relatively low proportion of total retinal cells and thus did not reach statistical significance, their proportion in Rs1 −/y mice increased six-fold (1.3%) compared to wild-type (0.2%), indicating a notable expansion of the microglial population (Fig. 3 B).

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