Placental Malperfusion Is Associated With Adverse Outcomes in Congenital Heart Disease and With Genetic Variants in Placental Developmental Pathways.

J Am Coll Cardiol · 2025 · PMC12919346 · PMID 41193091

Europe PMC DOI

hedged sentences

0.0540

closest p · 1.1× alpha

0.0600

boldest claim

The sentences

borderline significanceP = 0.054so close (0.05 < p ≤ 0.1)

PMP was associated with increased mortality in univariable analysis (unadjusted HR: 1.5; 95% CI: 1.03–2.17; P = 0.03), with borderline significance in multivariable analysis (adjusted HR: 1.44; 95% CI: 0.995–2.09; P = 0.054).

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a nonsignificant trendP = 0.06so close (0.05 < p ≤ 0.1)

There was a nonsignificant trend toward a longer index hospital length of stay in syndromic fetuses with PMP (44 days vs 26 days, P = 0.06).

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did not reach statistical significanceno p-value reported

Gene-level burden testing using the combining and collapsing multivariate test revealed 194 genes with a higher burden of variants in subjects with PMP (unadjusted P < 0.05), although these differences did not reach statistical significance after adjusting for multiple comparisons ( Supplemental Table 1 ).

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approaching significanceno p-value reported

In a multivariable model adjusting for the presence of genetic syndrome and single-ventricle physiology, the adjusted HR of 1.44 for PMP (95% CI: 0.995–2.90; P = 0.054) demonstrated a possible independent association with increased mortality approaching significance.

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