Oncostatin M upregulates CD73 via the MAPK pathway in keratinocytes to promote an adenosine-dependent anti-inflammatory response in psoriasis.

Front Immunol · 2026 · PMC12920598 · PMID 41727450

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showed a trendno p-value reported

As shown in Figure 7C , treatment of cells with the A 2A R agonist CGS21680 significantly reduced IL-8 release triggered by M5 stimulation, whereas cells treated with BAY606583 showed a trend toward reduced IL-8 levels.

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did not reach statistical significanceno p-value reported

Treatment of cells with the A 2B R agonist BAY606583 (1 μM) also reduced IL-8 levels in M5-stimulated cells, although the effect did not reach statistical significance ( Figure 6B ).

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