Barely Significant
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Single-cell epigenetic profiling reveals a tumor-intrinsic interferon response program in ccRCC tied to poor prognosis and <i>BAP1</i> loss.

Sci Adv · 2026 · PMC12922754 · PMID 41719400

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a suggestive trendno p-value reported
nominally significantno p-value reported
In multiplex immunofluorescence (mIF) data, BAP1 -mutant tumors ( n = 3) showed a suggestive trend toward higher overall CD8 + density and nominally significant increases in PD1 + CD8 + T cell density and the CD8 + PD1 + /CD8 + ratio across intratumoral (IT) and tumor-stroma interface (TSI) regions ( Fig. 5C and table S5).

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