Sexual dysfunction associated with selective serotonin reuptake inhibitors in adults with depression: a systematic review and meta-analysis.

Eur J Clin Pharmacol · 2026 · PMC12923408 · PMID 41721013

Europe PMC DOI

hedged sentences

0.1200

closest p · 2.4× alpha

0.1200

boldest claim

The sentences

showed a trendp = 0.12not close (p > 0.1)

Evaluation of sexual desire Meta-analysis incorporating 4 studies [ 19 , 20 , 27 ] showed a trend toward decreased sexual desire in SSRI users (RR = 1.40, 95% CI: 0.92–2.12, p = 0.12; I2 = 54%, 1,160 participants).

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did not reach statistical significanceno p-value reported

However, this difference did not reach statistical significance, though the point estimate suggests a clinically meaningful effect (Fig. 5 ).

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