Efficacy and safety of traditional Chinese classic prescriptions combined with metformin in the treatment of type 2 diabetes mellitus: a Bayesian network meta-analysis.

Front Pharmacol · 2026 · PMC12932438 · PMID 41756240

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did not reach statistical significanceno p-value reported

It is noteworthy that while lipid profiles and FPG improved, the pooled effect on HOMA-IR did not reach statistical significance.

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failed to reach statistical significanceno p-value reported

Met (n = 1)]; the Met monotherapy group constituted the largest sample size, and comparisons between GGQLD + Met and Met were the most frequently studied; integrated therapy showed no statistically significant differences in improving HOMA-IR compared to Met alone (all mean differences for herbal combinations failed to reach statistical significance with 95% confidence intervals crossing zero), therefore the current evidence does not support superior efficacy of combination regimens over Met monotherapy for improving HOMA-IR in patients with T2DM.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.