Nephron Number and Kidney Outcomes in IgA Nephropathy: A Retrospective Cohort Study.

Kidney360 · 2026 · PMC12935380 · PMID 40991351

Europe PMC DOI

hedged sentences

0.1200

closest p · 2.4× alpha

0.1200

boldest claim

The sentences

did not reach statistical significanceP = 0.12not close (p > 0.1)

The difference in eGFR slope between tertile 1 and tertile 3 was statistically significant (−0.34 ml/min per 1.73 m 2 per year, 95% CI, –0.55 to –0.13; P = 0.001), whereas the difference between tertile 2 and tertile 3 did not reach statistical significance (–0.18 ml/min per 1.73 m 2 per year; 95% CI, –0.40 to +0.04; P = 0.12).

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a significant trendno p-value reported

Overall, a significant trend was observed, showing that a higher number of nephrons was associated with a slower decline in eGFR ( P for trend <0.001).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.