Tissue-Based Multiomic Exploratory Analysis of the Urokinase Plasminogen Activator/uPAR System and Matrix Metalloproteinases in Stroma AReactive Invasion Front Areas-Positive Gastrointestinal Cancers.

Pathobiology · 2026 · PMC12935455 · PMID 41543983

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hedged sentences

0.0890

closest p · 1.8× alpha

0.1400

boldest claim

The sentences

showed a trendp value = 0.089so close (0.05 < p ≤ 0.1)

PLAUR and SERPINB2 both showed a trend toward upregulation in SARIFA-positive CRCs ( PLAUR : adjusted p value = 0.089, SERPINB2 : adjusted p value = 0.11).

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a clear trendp = 0.14not close (p > 0.1)

Even though we could again see a clear trend toward poorer survival of PAI-1-high CRC patients (hazard ratio [HR] and 95% confidence interval [CI]: 1.486 [0.87–2.54], p = 0.14; in 2017: p = 0.255 [ 20 ]), PAI-1 as well as uPA protein measurements via ELISA failed to significantly stratify CRC patients (for uPA: HR [95% CI]: 1.22 [0.72–2.069], p = 0.46).

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a nonsignificant trendno p-value reported

In CRC, SARIFA-positive tumours showed significantly higher expression of MMP2 compared to SARIFA-negative tumours ( p adjusted = 0.002), whereas MMP9 and MMP14 demonstrated a nonsignificant trend toward upregulation ( MMP9 : p adjusted = 0.11, MMP14 : p adjusted = 0.13) on bulk level.

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