Non-Smoking, Non-Drinking Oral Squamous Cell Carcinoma Is Associated with an Immune-Modulated Clinical Phenotype.

Cancers (Basel) · 2026 · PMC12938323 · PMID 41749807

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0830

boldest claim

The sentences

highly significantp < 0.001actually significant

Tumor Subsite Tumor anatomic distribution showed a highly significant difference between NSND and SD patients ( p < 0.001).

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showed a trendp = 0.083so close (0.05 < p ≤ 0.1)

Median OS was 81.2 months; NSND showed a trend toward improved OS ( p = 0.083) and improved OS after age/sex adjustment (HR 0.64, 95% CI 0.42–0.98), but not after full clinicopathologic adjustment; DSS did not differ ( p = 0.59).

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did not reach statistical significanceno p-value reported

Rates of LVI and PVI were lower in NSND patients, although these differences did not reach statistical significance.

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