Selective Benefit of Adjuvant Chemotherapy in Stage II dMMR Colon Cancer with High-Risk Features or Poorly Differentiated Histology: A Retrospective Study.

In contrast, ACT significantly improved or showed a trend towards improved outcomes in patients with aggressive biological features, such as PNI (DFS p = 0.038), poorly differentiated histology ( Figure 4 ), and LVI (OS p = 0.057).

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Among the 177 patients presenting with at least one high-risk feature, the 5-year OS and DFS were 98.6% and 95.6% in those receiving ACT, compared with 91.7% and 87.8% in those treated with surgery alone, although these differences did not reach statistical significance ( Figure 3 a,b).

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