Assessing Genetic Risk for Physical Activity and Its Interaction with Diet in Predicting Activity Levels and Weight Loss in the iMPROVE Study.

PRS-Diet Effects on PA and Weight Change Regarding PA outcomes (MET-mins/week), PGS002255 (HRC panel) showed a nominally significant negative association at the end of month 1 (Β = −3.73 × 10 7 , p = 0.021) ( Table 2 ), indicating that individuals with higher genetic risk scores were less likely to increase their activity levels during the early phase of the intervention.

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However, none of the PRSs were statistically significant predictors in the full models, and their overall model fits did not reach statistical significance.

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