Psychological Burden in Relapsing-Remitting Multiple Sclerosis: Sociodemographic and Clinical Determinants of Persistent Anxiety and Depression over a Six-Month Follow-Up.

Similarly, no significant differences were found between groups with minimal and severe depression (BDI 29–63) at 3 months, although a slight trend toward significance was observed at 6 months (U = 2.500, Z = −2.037, p = 0.042).

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However, participants with moderate depression (BDI = 20–28) had significantly lower BDI scores than those with severe depression (BDI = 29–63) at 3 months (U = 9, Z = −2.218, p = 0.027), with a marginally significant difference observed at 6 months (U = 11, Z = −2.010, p = 0.044).

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Finally, fear of dying showed a trend toward a decrease in higher scores (3), dropping from 17.1% at diagnosis to 2.9% at 6 months, which could reflect an improvement in coping with this symptom. 3.2.1.

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These results suggest that, although the global Friedman test did not reach statistical significance, meaningful differences in BDI scores were observed between specific time points, indicating potential changes that warrant further exploration.

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