Integrative omics and experimental validation reveal METTL17 and SLC27A1 as biomarkers and potential therapeutic targets in chronic kidney disease.

Front Immunol · 2026 · PMC12946038 · PMID 41766913

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hedged sentences

0.0890

closest p · 1.8× alpha

0.0890

boldest claim

The sentences

showed a trendP = 0.089so close (0.05 < p ≤ 0.1)

In contrast, SLC27A1 expression was positively correlated with serum creatinine (Pearson r = 0.467, P = 0.038; Figure 10c ) and showed a trend toward correlation with blood urea nitrogen (Pearson r = 0.390, P = 0.089), while no significant association was found with 24-hour proteinuria ( P > 0.05).

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did not reach statistical significanceno p-value reported

At the protein level, Western blot analysis confirmed a significant downregulation of METTL17, whereas SLC27A1 exhibited an upward trend that did not reach statistical significance, likely reflecting reduced statistical power arising from the limited sample size.

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