Integrative analysis of T cell subset-specific ICOS expression and tumor HLA class I/II expression in lung adenocarcinoma: implications for their interaction and clinical outcome.

Cancer Immunol Immunother · 2026 · PMC12950126 · PMID 41762250

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closest p

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did not reach statistical significancep = 0.060so close (0.05 < p ≤ 0.1)

showed a trendno p-value reported

By contrast, in the HLA-DR-strong group, the ICOS-high group showed a trend toward longer cancer-specific survival (CSS), although this trend did not reach statistical significance ( p = 0.060).

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