Comparison of weekly docetaxel regimens in prostate cancer: a systematic review and frequentist network meta-analysis.

Explor Target Antitumor Ther · 2026 · PMC12950338 · PMID 41773084

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did not reach statistical significanceno p-value reported

Most adverse events did not reach statistical significance and were characterized by varying degrees of heterogeneity.

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failed to reach statistical significanceno p-value reported

Outcomes Primary outcomes PSA response rate An NMA of the PSA response rate (5 studies, 757 patients, and three treatment regimens assessed) showed a lower PSA response rate on using triweekly (RR: 0.79; 95% CI: 0.52–1.22; p = 0.23) or biweekly docetaxel (RR: 0.86; 95% CI: 0.53–1.41; p = 0.48) as compared to weekly docetaxel, although the difference failed to reach statistical significance ( Figure 2A ).

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