Although this trend did not reach statistical significance, likely owing to the small sample size, the findings imply a potential mechanistic link between ICD induction and favorable responses to immune checkpoint inhibition in recurrent BC.
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Immunogenic Tumor Cell Death Induced by Neoadjuvant Chemotherapy in Patients With Muscle-Invasive Bladder Cancer: An Immunohistochemical Analysis.
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In multivariable analysis, only histological subtype (HR 4.48, 95% CI 1.13-17.6, P = 0.03) remained significantly associated with all-cause mortality, whereas upregulation of HMGB1 and pT stage ≥ pT3 (HR, 0.30; 95% CI, 0.07-1.22; P = 0.09 and HR, 3.33; 95% CI, 0.84-13.3; P = 0.09, respectively) showed a trend toward association (Table 2 ).