The immune checkpoint LAG-3 is expressed by melanoma cells and correlates with clinical progression of the melanoma.

However, these differences did not reach statistical significance in our small cohort.

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The absolute values for ORR, DCR, median PFS and median OS showed a trend toward a more favorable performance in patients with high LAG-3 expression (cutoff ≥1% vs < 1%). 77 It would be interesting to perform similar analyses as in our study on a cohort which underwent anti-PD-1/anti-LAG-3 combination treatment as in the RELATIVITY-020 trial.

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