Enzymatic Remodelling of Tumour Microenvironment Enhances Anti-CEACAM5 CAR T-Cell Efficacy Against Colorectal Cancer.

Whilst trypsin and hyaluronidase treatment showed a trend toward increased IFN‐γ‐secreting CAR T cells, the differences did not reach statistical significance, likely due to the inherent variability in IFN‐γ measurements (Figure 4F ).

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