Population pharmacokinetic model and dosing nomogram for daptomycin in adult patients with serious Gram-positive infections: emphasizing the role of loading doses and renal function-based adjustment.

Similarly, the difference in daptomycin AUC 072h between patients with and without elevated myoglobin did not reach statistical significance (median AUC 072h of 3,095 vs 3,013 mg·h/L, P = 0.3388).

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As expected, the base model exhibits a clear trend between eGFR and the individual deviations in CL, whereas this trend is eliminated in the final model after inclusion of eGFR as a covariate.

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