MAGL Inhibition Relieves Psoriasiform Inflammation and Pruritus Via Modulation of ALOX12-12-HETE Axis in Mice.

Inflammation · 2026 · PMC12960361 · PMID 41774275

Europe PMC DOI

hedged sentences

0.0620

closest p · 1.2× alpha

0.1003

boldest claim

The sentences

showed a trendp = 0.062so close (0.05 < p ≤ 0.1)

On day 3, the number of scratches in the JZL + IMQ group showed a trend toward reduction compared with the IMQ group ( p = 0.062), while the difference between the JZL + IMQ + CB2R −/− and JZL + IMQ groups reached statistical significance.

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did not reach statistical significancep = 0.1003not close (p > 0.1)

Treatment with JZL184 produced a downward trend relative to the IMQ group, although this change did not reach statistical significance ( p = 0.1003), while co-administration of AM630 exerted no additional effect compared with JZL184 alone (Fig. 5 A).

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