Osteoarthritis: molecular pathogenesis and potential therapeutic options.

Signal Transduct Target Ther · 2026 · PMC12960730 · PMID 41781374

Europe PMC DOI

hedged sentence

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closest p

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failed to reach statistical significanceno p-value reported

showed a trendno p-value reported

In phase II clinical trials involving 285 RA patients, VX-740 showed a trend toward symptom improvement but failed to reach statistical significance.

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