Voriconazole as a Secondary Prophylaxis for Invasive Fungal Infections in Allogeneic Hematopoietic Stem Cell Transplantation: Real-world Evidence From a Major Transplantation Center in Taiwan.

For post-HSCT trough concentrations (n = 70), the Fine–Gray subdistribution hazard model showed a trend toward a lower risk of breakthrough IFI in the ≥1 mg/L group compared with <1 mg/L (sHR = 0.18, 95% CI 0.03–1.27, P = .0852).

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This finding suggests that prolonged periods of subtherapeutic voriconazole exposure may be associated with an increased risk of breakthrough IFIs, although the trend did not reach statistical significance.

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