From byproduct to biotherapeutic: Comparative study of buffy coats and leukoreduction system chambers for NK cell-based immunotherapies.

iScience · 2026 · PMC12962150 · PMID 41797916

Europe PMC DOI

hedged sentences

0.0538

closest p · 1.1× alpha

0.3850

boldest claim

The sentences

a clear trendp = 0.0538so close (0.05 < p ≤ 0.1)

LRSC p = 0.433; Figure 1 B), whole PB samples yielded significantly fewer PBMCs than LRSCs ( p < 0.0001) and showed a clear trend toward lower PBMC counts compared to BCs ( p = 0.0538; Figure 1 C).

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an unexpected trendp = 0.0583so close (0.05 < p ≤ 0.1)

Multivariate regression analysis revealed an unexpected trend toward an inverse correlation between PB basophil counts and NK cell yield from LRSCs ( p = 0.0583; Figure S2 , Table S2 ), suggesting that lower circulating basophil levels may be associated with improved NK cell recovery after plateletpheresis.

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did not reach statistical significancep = 0.385not close (p > 0.1)

By day 14 of culture ( Figure 2 C), both groups exhibited a decline in cytotoxicity, however, this reduction did not reach statistical significance at any E:T ratio for either BC-derived NK cells (10:1 p = 0.385; 5:1 p = 0.598; 3:1 p = 0.178; 1:1 p = 0.082; 0.5:1 p = 0.060) or LRSC-derived NK cells (10:1 p = 0.076; 5:1 p = 0.657; 3:1 p = 0.834; 1:1 p = 0.194; 0.5:1 p = 0.165).

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