Active Macropinocytosis, Lipid Catabolism, and Exhausting Immune Microenvironment of Ascites Tumor Cells Are Involved in Resistance to Platinum-Based Therapy in Patients With High-Grade Serous Ovarian Cancer.

MedComm (2020) · 2026 · PMC12966806 · PMID 41799929

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.0780

boldest claim

The sentences

showed a trendp = 0.055so close (0.05 < p ≤ 0.1)

“HALLMARK IL6 JAK STAT3 signaling” ( p = 0.027) and “HALLMARK inflammatory response” ( p = 0.027) were scored lower in the resistant group, implying suppressed immune activation and inflammation, while “HALLMARK adipogenesis” showed a trend toward higher score ( p = 0.055), suggesting that resistant cells may adopt adipocyte‐like traits such as enhanced lipid storage [ 32 , 33 ].

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did not reach statistical significancep = 0.078so close (0.05 < p ≤ 0.1)

Similarly, SKOV3/DDP exhibited greater TMR‐Dextran uptake than SKOV3 ( p < 0.001), with EIPA markedly reducing uptake in SKOV3/DDP ( p < 0.001), whereas reduction in SKOV3 did not reach statistical significance ( p = 0.078) (Figure 6E ; Table S20 ).

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