Clinical Features, Mechanisms, and Management of Anxiety in Youth with Tic Disorders: A Narrative Review.

As an atypical antipsychotic and a first-line agent for TD, Aripiprazole showed a trend toward improving anxiety symptoms in one adult study. 83 Specifically, Selective Serotonin Reuptake Inhibitors are commonly used for comorbid anxiety, obsessive-compulsive, and depressive symptoms. 84 An ongoing randomized controlled trial is comparing the efficacy of sertraline versus placebo for anxiety in children and adolescents with neurodevelopmental disorders, including TD, ADHD, and ASD (ID: NCT06081348 ).

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While it also showed a positive trend for anxiety improvement, the between-group difference in final anxiety scores did not reach statistical significance. 85 These mixed and preliminary findings underscore that there is currently no standardized pharmacological protocol for treating anxiety in TD.

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