The predictive value of serum neurofilament light chain in achieving no evidence of disease activity-3 (NEDA-3) status in treatment-naïve patients with multiple sclerosis.

In multivariable regression models, a negative trend towards disease duration prior to the baseline sNfL measurement and baseline sNfL Z-score was observed [adjusted standardized linear regression coefficient (beta)—β: −0.03; 95%CI: −0.05– −0.01; p -value: 0.091].

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Nevertheless, this association failed to reach statistical significance among patients treated with any DMT (Fig. 3 ; Table 3 ).

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