Metabolome contribution to sex differences in the link between alcohol consumption and type 2 diabetes: a prospective analysis in the Hispanic Community Health Study/Study of Latinos.

In contrast, there was a positive association between MAMS and risk of T2D in males, though it did not reach statistical significance ( P -trend = 0.17) ( Supplemental Figure 9A ).

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Similarly, a negative trend of association between FAMS and risk of incident insulin resistance was also found in females, although it did not achieve statistical significance ( Supplemental Figure 9B ).

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We found a highly significant linear association between the sex-specific AMS and alcohol consumption levels in females (P-trend < 0.0001) and males (P-trend < 0.0001), respectively ( Figure 2 C).

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