Polymorphism in the tumour necrosis factor receptor II gene is associated with circulating levels of soluble tumour necrosis factor receptors in rheumatoid arthritis.

Arthritis Res Ther · 2005 · PMC1297570 · PMID 16277675

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failed to reach statistical significanceno p-value reported

An identical trend was observed in patients with early disease, although the data failed to reach statistical significance.

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highly significantno p-value reported

In both populations studied here, we found a highly significant association between increasing levels of both sTNFRs and age, which was independent of disease duration.

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a significant trendno p-value reported

Multiple regression analyses corrected for age, sex and disease duration revealed a significant trend toward decreasing sTNF-RI and sTNF-RII levels across the TNF-RII genotypes (TT > TG > GG) of patients with established disease ( P for trend = 0.01 and P for trend = 0.03, respectively).

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