Fish (Alaska Pollock) protein intake attenuates age-related short-term memory decline through gut microbiota modulation.

Additionally, non-fasting blood glucose levels showed a trend toward decreased levels in the SAMR1 + APP group compared to the SAMR1 + Cas group, but without statical significance; however, this trend was not observed in SAMP8 mice (Table 1 : SAMR1 + Cas, 197.8 ± 21.7; SAMR1 + APP, 149.9 ± 8.5; SAMP8 + Cas, 194.0 ± 9.7; 194.5 ± 12.2 mg/dL, two-way ANOVA: diet effect F (1, 44) = 3.07, p > 0.05 ; strain effect F (1, 44) = 2.27, p > 0.05; and diet–strain interaction F (1, 44) = 3.20, p > 0.05).

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Conclusions Although the cognitive deficit in SAMP8 + Cas versus SAMR1 + Cas control group did not show a significant trend, APP diet supplementation significantly improved short-term memory performance in SAMP8 mice compared with the SAMP8 + Cas control.

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