Double-blind, sham-controlled, pilot study of trigeminal nerve stimulation for autism spectrum disorder.

In uncorrected exploratory analyses, changes of four qEEG relative band powers exhibited nominally significant linear correlation with clinical improvements.

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While between-group differences did not reach statistical significance for all measures, the TNS group exhibited consistent within-group improvements across adaptive, executive, and attentional domains, suggesting a potential trend toward developmental benefits that warrants further validation in larger samples.

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