Repurposing dipeptidyl peptidase-4 inhibitor for Parkinson's disease prevention: A drug-target Mendelian randomization study.

Neurotherapeutics · 2026 · PMC12976525 · PMID 41469306

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showed a trendno p-value reported

In male participants, both T2DM-associated and non-associated IVs showed a trend toward increased risk of PD.

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did not reach statistical significanceno p-value reported

In replication analyses using data from UK Biobank and FinnGen, the associations did not reach statistical significance under the default IVW methods but showed suggestive evidence of association (IV eQTL : OR 1.27 [0.99–1.61], p = 0.055; IV pQTL : OR 1.1 [0.98–1.23], p = 0.109).

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