Dietary tributyrin supplementation in Parkinson's disease: An open-label target engagement study.

Neurotherapeutics · 2026 · PMC12976542 · PMID 41271518

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did not reach statistical significanceno p-value reported

Furthermore, the small sample size utilized for feasibility purposes in the setting of unknown effect sizes appears to be limited in regard to statistical power, as there were a number of outcomes that trended toward improvement but did not reach statistical significance.

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failed to reach statistical significanceno p-value reported

Neuropsychiatric: Treatment model trended toward accounting for greater portion of variance in PDQ-39 total score than the confounder model ( χ 2 = 2.733, p = 0.0983), but failed to reach statistical significance.

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