Targeting dual specificity tyrosine-phosphorylation-regulated kinase 1A mitigates tauopathy and enhances recovery after repetitive head injury.

In parallel, SM07883-treated animals showed a trend toward reduced latencies (p = 0.71) and path lengths (p = 0.46) to locate the target hole in the Barnes maze, alongside increased exploratory velocity, but these effects were not statistically significant compared with RHI-V animals.

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An injury effect was observed with the RHI-V groups performing the worst, requiring on average 41 ± 5.1 s to reach the target zone while RHI-SM07883 exhibited a trend (p = 0.71) toward shorter latency compared to the RHI-V group; however, this difference did not reach statistical significance.

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