Multi-omics dynamic profiling reveals predictive biomarkers for first-line immunochemotherapy in extensive-stage small-cell lung cancer.

3 B) plots revealed distinctions in distribution between the two groups, with a clear trend toward separation, although certain regions overlapped, suggesting the presence of both shared and unique lipidomic characteristics.

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Figure 7 E showed the changes in three proteins, ACIN1, ACSL4, and PHGDH were significantly down-regulated in R group at both baseline and after one cycle of treatment compared with NR group, while the relative content of PHGDH showed a trend of continued down-regulation from baseline after one cycle of treatment.

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