Integration of gold standard arthroscopy, MRI and synovial histopathology outcomes for enhancing early knee osteoarthritis diagnosis.

However, when the different knee regions were analyzed separately, the adjusted p-values did not reach statistical significance, although a clear trend was observed, suggesting that cartilage damage may be more pronounced in the medial femorotibial joint (MFTJ), whereas bone marrow lesions appear to predominate in the patellofemoral joint (PFJ) (Table 3 ).

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Nevertheless, when both conditions were combined, Moderate KOA patients showed a statistical trend towards a higher prevalence compared to Early patients.

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