Heart failure evidence update 2026.

Heart Fail Rev · 2026 · PMC12979370 · PMID 41811612

Europe PMC DOI

hedged sentences

0.0590

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

near-significantp = 0.059so close (0.05 < p ≤ 0.1)

placebo and showed a near-significant reduction in the primary composite of total HF hospitalisations and CV death (RR 0.79, 95% CI 0.62–1.01, p = 0.059), driven by fewer total HF hospitalisations (RR 0.74, 95% CI 0.58–0.94, p = 0.013), with no difference in CV death (HR 0.96, 95% CI 0.70–1.32, p = 0.81) [ 56 ].

also in 1,099 other papers

did not reach statistical significanceno p-value reported

This benefit was driven predominantly by a lower incidence of worsening HF events (HR 0.59; 95% CI 0.41–0.82; p = 0.0019), while the reduction in CV death did not reach statistical significance (HR 0.82; 95% CI 0.57–1.16).

also in 53,799 other papers

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