Atherosclerotic plaque burden in the aorta showed a decreasing trend with diacerein treatment, accompanied by reduced expression of pro-inflammatory cytokines, including TNF-α.
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Diacerein improves liver fibrosis, steatosis, and atherosclerosis in ApoE knockout mice.
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Furthermore, diacerein showed a trend toward reduced aortic atherogenic plaques and attenuated the inflammatory response in the heart and adipose tissue in ApoE knockout mice, suggesting potential anti-atherosclerotic effects.
IL-6 expression showed a decreasing trend following diacerein treatment, although the change did not reach statistical significance (Fig. 1 B).
TIMP1 levels exhibited an increasing trend, correlating with the progression of metabolic disease severity from metabolic associated fatty liver disease to metabolic associated steatohepatitis (Fig. 6 C).