Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses.

Nat Commun · 2026 · PMC12979737 · PMID 41807427

Europe PMC DOI

hedged sentences

0.2800

closest p · 5.6× alpha

0.2800

boldest claim

The sentences

did not reach statistical significancep = 0.28not close (p > 0.1)

Similarly, elevated CD8_ZNF683 levels correlated with better prognosis in the Kim cohort (p = 0.00073), although this association did not reach statistical significance in the Ravi cohort ( p = 0.28) (Fig. 3H ).

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showed a trendno p-value reported

In contrast, BMs showed a trend of enrichment proliferating CD8+ T cells (CD8_Cycling).

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