IRF2 deficiency disrupts pyroptosis, NK cell interferon-γ production and resistance to Francisella.

1J,K ), although the observed differences in GSDMD transcript levels did not reach statistical significance in the latter case.

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Notably, granzyme A expression showed a trend toward upregulation, as shown in Fig. 6G (blood) and Fig. 6J (spleen), suggesting that, in the presence of IFN-γ, IRF2-deficient NK cells may retain some cytotoxic potential despite their immature status.

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