Exposure of male mice to nicotine leads to metabolic dysfunction in their male and female offspring.

J Endocr Soc · 2026 · PMC12981328 · PMID 41836600

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hedged sentences

0.0520

closest p · 1.0× alpha

0.0520

boldest claim

The sentences

did not reach statistical significanceP = .052so close (0.05 < p ≤ 0.1)

Additionally, we found a slight increase in ghrelin levels, although this latter finding did not reach statistical significance ( P = .052) ( Fig. 2F ).

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near-significantno p-value reported

Despite this variation, metabolite analyses conducted on plasma isolated postmortem after overnight fasting revealed a substantial reduction in insulin levels and a near-significant increase in ghrelin levels in female participants from the nicotine group compared to the control group.

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