LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models.

On the other hand, after 24 h of incubation with 300 μg/mL LDL, SLC1A2 mRNA levels appeared to show an increasing trend (# p = 0.0857), suggesting a potential effect that warrants further investigation.

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C6 cells exposed to 300 μg/mL LDL showed a trend toward increased NRF2 gene expression after 24 h ( F (2, 9) = 3.253, p = 0.0865, Dunnett's post hoc test: Ctrl vs. 50 μg/mL: p = 0.2514; Ctrl vs. 300 μg/mL: # p = 0.0576), which became statistically significant after 48 h of incubation ( F (2, 8) = 15.18, p = 0.0019, Dunnett's post hoc test: Ctrl vs. 50 μg/mL: p = 0.9581; Ctrl vs. 300 μg/mL: ** p = 0.0020) (Figure 5e ). 3.10.

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However, this difference did not reach statistical significance ( p = 0.1030), likely reflecting the variability inherent to the small sample size ( n = 3).

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