Phosphatidylcholine and CHPT1 as Central Drivers of Chemoresistance in Colorectal Cancer: Lipidomic and Functional Insights.

Cells · 2026 · PMC12984110 · PMID 41827872

Europe PMC DOI

hedged sentences

0.1400

closest p · 2.8× alpha

0.1400

boldest claim

The sentences

did not reach statistical significancep = 0.14not close (p > 0.1)

Although this difference did not reach statistical significance in this cohort (log-rank p = 0.14), these data suggest that elevated CHPT1 levels may be linked to poorer clinical outcomes and support the potential relevance of CHPT1 as a candidate biomarker and therapeutic vulnerability in CRC. 3.5.

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showed a trendno p-value reported

Kaplan–Meier analysis showed a trend toward reduced overall survival in patients with high CHPT1 expression compared with those with low expression ( Figure 6 B).

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