A phase 1 study of berzosertib (M6620, VX-970) in combination with cisplatin and radiation in patients with locally advanced head and neck squamous cell carcinoma (ETCTN 9950).

Cancer · 2026 · PMC12984462 · PMID 41823504

Europe PMC DOI

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did not reach statistical significanceno p-value reported

Although directional differences were observed in some comparisons, these did not reach statistical significance and should be interpreted cautiously given the small sample size and the exploratory nature of the analyses.

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showed a trendno p-value reported

Patients with HPV(+) showed a trend toward better PFS and OS, as would be expected.

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